Cyanocobalamin, ascorbic acid and pteroylglutamates in normal and megaloblastic bone marrow.
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چکیده
منابع مشابه
A Case of Megaloblastic Anemia with Thrombocytopenia
Megaloblastic anemias are a group of hematologic disorders in which abnormal DNA synthesis causes blood and bone marrow disorders. This type of anemias occurs as a result of folic acid deficiency or impaired vitamin B12 absorption. The prevalence of this type of anemia is highly variable worldwide and megaloblastic anemia caused by lack of vitamin B12 (cyanocobalamin) is rare during pregnancy [...
متن کاملUSE OF MYELOPEROXIDASE INDEX AS A SUITABLE TOOL TO MONITOR RESPONSE TO THERAPY IN PATIENTS WITH MEGALOBLASTIC ANEMIA
Repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. The objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic erythroid progeny. It is possible to follow up megaloblastic ...
متن کاملThe present position of the treatment of megaloblastic anaemias.
A distinction must be drawn between megaloblastic and macrocytic anaemias. Not all macrocytic anaemias are megaloblastic and not all megaloblastic anaemias are macrocytic. The term macrocytosis refers to the size of red blood cells in the peripheral blood. The mean cell volume of packed red blood cells (haematocrit) may be greater than normal, or the diameters of a proportion of red blood cells...
متن کاملMegaloblastic bone marrow changes after repeated nitrous oxide anaesthesia. Reversal with folinic acid.
A seriously ill patient was found to have megaloblastic changes in his bone marrow after a nitrous oxide anaesthesia which lasted for 105 min. After an interval of 7 h a second nitrous oxide anaesthetic was administered, during which the patient received 30 mg of folinic acid. His marrow was normal when assessed 4 h later.
متن کاملCongenital Methylmalonic Aciduria - Homocystinuria With Megaloblastic Anemia : Observations on Response to Hydroxocobalamin and on the Effect of Homocysteine and Methionine on the Deoxynridine Suppression Test
Congenital methylmalonic aciduria-homocystinuria, a disorder with an incompletely defined cobalamin abnormality. has not been accompanied by megaloblastosis in most of the initially described cases. This has raised questions about the exact role of cobalamin in relation to megaloblastic anemia. Therefore, we present our observations on a patient with this syndrome whose manifestations conformed...
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عنوان ژورنال:
- Blood
دوره 15 شماره
صفحات -
تاریخ انتشار 1960